Effects of Intravenous and Intraperitoneal Thermal Perfusion Chemotherapy after Laparoscopic Surgery on Tumor Markers,Tumor Recurrence and Survival in Patients with Colorectal Cancer
Objective To analyze the impact of intravenous and intraperitoneal thermal perfusion chemotherapy after laparoscopic surgery on patients with colorectal cancer.Methods 74 patients with postoperative colorectal cancer treated with laparoscopic surgery at National Pharmaceutical North Hospital from January 2020 to January 2023 were selected as the research objects and randomly divided into a control group and an observation group,with 37 patients in each group,using a random number table method.The control group received intravenous chemotherapy after surgery,while the observation group received intraperitoneal thermal perfusion chemotherapy.Compare tumor markers,recurrence rate,survival rate,and adverse reactions between the two groups.Results The postoperative levels of carcinoembryonic antigen was(5.29±0.50)ng/mL,carbohydrate antigen 125 was(25.71±2.89)U/mL,and carbohydrate antigen 199 was(26.52±2.57)U/mL in the observation group were lower than(8.58±1.29)ng/mL,(32.35±4.76)U/mL,and(32.63±3.70)U/mL in the control group,the differences between groups were statistically significant(P＜0.05).There was no statistically significant difference between the two groups in terms of recurrence rate,survival rate,and incidence of adverse reactions(P＞0.05).Conclusion Intravenous and intraperitoneal thermal perfusion chemotherapy after laparoscopic surgery can kill cancer cells in patients with colorectal cancer,reduce recurrence,improve survival rate,and have no serious adverse reactions.
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