Efficacy and Safety of Clarithromycin Combined with Omeprazole and Metronidazole in the Treatment of Helicobacter Pylori Associated Gastritis in Children
Objective To investigate the efficacy and safety of clarithromycin combined with omeprazole and metronidazole in the treatment of helicobacter pylori(Hp)associated gastritis in children.Methods 56 children with Hp associated gastritis admitted to Jinan Jiyang District People's Hospital from December 2022 to December 2023 were selected as the research objects and were divided into a control group and a study group according to random number table method,with 28 cases in each group.The control group was treated with amoxicillin combined with omeprazole and metronidazole,while the study group was treated with clarithromycin combined with omeprazole and metronidazole.Both groups were treated for 10 days.The clinical efficacy,serum inflammatory factors,immune function and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 92.86%,which was higher than 71.43%of the control group,the difference was statistically significant(P＜0.05).After treatment,the levels of C-reactive protein,interleukin-17 and interleukin-6 in the study group were lower than those in the control group,the differences between the groups were statistically significant(P＜0.05).After treatment,the levels of CD3+and CD4+in the study group were higher than those in the control group,and the level of CD8+was lower than that in the control group,the differences between the groups were statistically significant(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Clarithromycin combined with omeprazole and metronidazole can regulate the levels of inflammatory factors in children with Hp associated gastritis,improve their immune function,and have definite clinical efficacy and good safety.
Helicobacter pylori associated gastritis in childrenClarithromycinOmeprazoleMetronidazole
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