Clinical Efficacy of Low Molecular Weight Heparin Assisted Letrozole in the Treatment of Infertility Induced by PCOS and Its Impact on Patients'Endometrial Receptivity
Objective To investigate the clinical efficacy of low molecular weight heparin assisted letrozole in the treatment of infertility induced by polycystic ovary syndrome(PCOS)and its influence on patients'endometrial receptivity.Methods 74 infertility patients caused by PCOS admitted to Juye County Maternal and Child Health Hospital of Heze city from January 2022 to March 2023 were selectedas the research objects and were divided into a control group and an observation group by random number table method,with 37 cases in each group.The control group was treated with letrozole,and the observation group was treated with low molecular weight heparin combined with letrozole.Both groups received continuous treatment for 3 menstrual cycles.The clinical efficacy,serum sex hormone levels,endometrial receptivity,ovulation and pregnancy and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate,pregnancy rate and ovulation rate of the observation group were 94.59%,78.39%and 91.90%,respectively,which were higher than 75.67%,51.35%and 72.97%of the control group,and the differences between groups were statistically significant(P＜0.05).The levels of FSH,luteinizing hormone and estradiol in the observation group were(18.45±3.45)mIU/mL,(28.45±4.37)mIU/mL and(210.22±20.23)pg/mL,respectively.It was higher than(5.07±1.29)mIU/mL,(26.37±4.12)mIU/mL,(162.52±18.42)pg/mL in control group,and the differences between groups were statistically significant(P＜0.05).The endometrial thickness of the observation group was(9.76±1.04)mm,which was thicker than that of the control group(7.35±0.93)mm.The spiral artery pulse index and resistance index of the endometrial were(1.28±0.23)and(0.56±0.13),respectively,which were lower than that of the control group(1.72±0.34)and(0.67±0.11).The differences between groups were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The effect of low molecular weight heparin assisted letrozole on infertility caused by PCOS is significant,which can increase endometrial receptivity and regulate serum sex hormone levels,and is conducive to the improvement of ovulation and pregnancy in patients with high safety.
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