Effects of Dihydroxyproprofylline Combined with Budesonide on Lung Function and Blood Gas Analysis in Patients with AECOPD Complicated with Respiratory Failure
Objective To investigate the effects of dihydroxyproprofylline combined with budesonide on lung function and blood gas analysis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods Eighty-six patients with AECOPD complicated with respiratory failure admitted to Yicheng District People's Hospital from May 2021 to May 2023 were selected as the study object,and were divided into a control group and an observation group according to random number table,with 43 patients in each group.The control group was treated with dihydroxyproprofylline,and the observation group was treated with budesonide on the basis of control group.Both groups were treated for 1 week.The clinical efficacy,lung function index,blood gas analysis index and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The levels of forced vital capacity(FVC),forced expiratory volume at the first second(FEV1)and FEV1/FVC in the observation group were greater than those in the control group,and the level of arterial blood oxygen partial pressure was higher than that in the control group,and the differences between groups were statistically significant(P＜0.05).The partial blood pressure of carbon dioxide in the observation group was(36.92±5.34)mmHg,lower than(42.41±4.28)mmHg in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Dihydroxyproprofylline combined with budesonide in the treatment of AECOPD patients with respiratory failure can restore lung function,adjust blood gas analysis indexes,and have good safety and efficacy.
Acute exacerbation of chronic obstructive pulmonary diseaseRespiratory failureDihydroxyproprofyllineBudesonideLung functionBlood gas analysis
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