Effect of Recombinant Human Erythropoietin Combined with Roxadustat in the Treatment of Maintenance Hemodialysis Renal Anemia and Its Impact on Iron Metabolism Indicators
Objective To explore the efficacy of recombinant human erythropoietin combined with roxadustat in maintenance hemodialysis patients with renal anemia and its impact on iron metabolism indicators.Methods Selecting 90 patients with maintenance hemodialysis renal anemia admitted to Jianhe County People's Hospital from December 2020 to August 2023 as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 45 cases in each group.The control group received treatment with recombinant human erythropoietin,while the observation group received combined treatment with roxadustat on the basis of the control group.Both groups were treated for 2 months.The two groups'clinical efficacy,iron metabolism indicators,anemia indicators,and adverse reactions were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,the differences was statistically significant(P＜0.05);before treatment,comparison of various iron metabolism indicators and anemia indicators between the two groups,there was no statistically significant differences between groups(P＞0.05);after treatment,the levels of serum ferritin,transferrin saturation,transferrin,hemoglobin,red blood cell count,and hematocrit in the observation group were higher than those in the control group,while the levels of hepcidin and soluble transferrin receptor in the observation group were lower than those in the control group,the differences between groups were statistically significant(P＜0.05);comparison of adverse reactions between two groups,the differences was not statistically significant(P＞0.05).Conclusion The use of recombinant human erythropoietin combined with roxadustat in maintenance hemodialysis patients with renal anemia can effectively regulate iron metabolism indicators and anemia indicators,and is safe and reliable.
Maintenance hemodialysisRenal anemiaRecombinant human erythropoietinRoxadustatIron metabolism indicatorsAnemia indicators
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