Effect of Combined Treatment with Ambroxol and Linezolid on Blood Gas Analysis and Pulmonary Inflammatory Response in Elderly Patients with Severe Pneumonia
Objective To explore the therapeutic effect of the combination therapy of ambroxol and linezolid in elderly patients with severe pneumonia.Methods A retrospective analysis was conducted on the clinical data of eighty elderly patients with severe pneumonia admitted to the hospital from March 2021 to April 2023.They were divided into a control group and an observation group according to different treatment methods,with 40 cases in each group.The control group was treated with linezolid alone,while the observation group was treated with ambroxol in addition to the control group.Both groups were treated continuously for 2 weeks.Compare the blood gas analysis indicators,inflammatory response,clinical efficacy,and adverse reactions between two groups.Results After treatment,the arterial oxygen saturation and arterial oxygen partial pressure levels in the observation group were higher than those in the control group,while the arterial carbon dioxide partial pressure levels were lower than those in the control group,and the differences between the groups were statistically significant(P＜0.05).After treatment,the average levels of interleukin-6,interleukin-8,and tumor necrosis factor-α in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P＜0.05).The total effective rate of the observation group was 95.00%,which was higher than the control group's 77.50%,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combined use of ambroxol and linezolid in elderly patients with severe pneumonia has significant therapeutic effects,can effectively improve the level of blood gas analysis indicators,alleviate pulmonary inflammatory reactions,and is safe to use.
Severe pneumoniaAmbroxolLinezolidBlood gas analysisInflammatory responseClinical efficacy
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