Effect of Vitamin D2 Combined with Azithromycin on Serum Immunoglobulin and Inflammatory Factors in Children with Community Acquired Pneumonia
Objective To explore the effects of vitamin D2 combined with azithromycin on serum immunoglobulins and inflammatory factors in children with community acquired pneumonia(CAP).Methods Eighty children with CAP admitted to Chengyang District People's Hospital in Qingdao from January to December 2023 were selected as the research subjects.Divided into a control group and an observation group using a random number table method,with 40 cases in each group.The control group received treatment with azithromycin,children in the observation group were treated with vitamin D2 on the basis of the control group.Compare the improvement of symptoms,serum immunoglobulin levels,inflammatory factor levels,and adverse reactions between two groups.Results The time for body temperature recovery,cough improvement,and disappearance of lung rales in the observation group were all shorter than those in the control group,the differences between groups were statistically significant(P＜0.05);the levels of immunoglobulin IgA,IgG,and IgM in the observation group were higher than those in the control group.The levels of C-reactive protein,interleukin-6,procalcitonin,and tumor necrosis factor-α were all lower than those of the control group,the differences between groups were statistically significant(P＜0.05);comparison of adverse reactions between two groups,there was no statistically significant difference between groups(P＞0.05).Conclusion The combination of vitamin D2 and azithromycin has a significant effect on children with CAP,which can promote the increase of serum immunoglobulin indicators,alleviate inflammatory reactions,shorten symptom relief time,and is safe.
Community acquired pneumoniaAzithromycinVitamin D2Serum immunoglobulinInflammatory factorsAdverse reactions
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