Effects of Budesonide Formoterol Combined with Ipratropium Bromide on Pulmonary Function and Symptom Resolution Time in Patients with Acute Exacerbation of COPD
Objective To investigate the effects of budesonide formoterol combined with ipratropium bromide on patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 90 patients with acute exacerbation of COPD admitted to the Respiratory and Critical Care Medicine Department of Yantai Laiyang Central Hospital from March 2022 to June 2023 were selected as the study objects and were divided into a control group and an observation group according to random number table method,with 45 cases in each group.The control group was treated with ipratropium bromide,the observation group was treated with budesonide formoterol on the basis of the control group,and the two groups were treated for 7 days.Lung function,time of symptom disappearance,inflammation and adverse reactions were compared between the two groups.Results The disappearance time of dyspnea,shortness of breath,wheezing sound and cough in observation group was shorter than that in control group,and the differences between groups werestatistically significant(P＜0.05).After treatment,the levels of forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and FEV1/FVC in the observation group were greater than those in the control group,and the differences between groups were statistically significant(P＜0.05).The levels of C-reactive protein,interleukin-6,tumor necrosis factor-α in observation group were lower than those in control group,and the differences between groups were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Budesonide formoterol and ipratropium in the treatment of acute exacerbation of COPD can accelerate symptoms,reduce or disappear inflammation,improve lung function,and reduce adverse reactions.
Chronic obstructive pulmonary diseaseAcute exacerbation stageBudesonide formoterolIpratropium bromideLung function
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