Comparison of Sequential Therapy and Standard Triple Therapy on Hp Clearance Effect and Diurnal Changes in Gastric pH Value in Patients with Hp Infected Gastric Ulcers
Objective To compare the efficacy of sequential therapy and standard triple therapy in the treatment of patients with Helicobacter pylori(Hp)infected gastric ulcers.Methods Seventy-four patients with Hp infected gastric ulcers admitted to the First Traditional Chinese Medicine Hospital of Guanxian County,Shandong Province from July 2020 to July 2023 were selected as the research subjects,and were divided into a control group and an observation group using a random number table method,with 37 cases in each group.The control group received standard triple therapy,while the observation group received sequential therapy.Compare the Hp clearance effect,clinical efficacy,diurnal changes in gastric pH value,gastric ulcer healing,and adverse reactions between two groups.Results The Hp clearance rate in the observation group was 95.59%,the total effective rate of treatment was 94.59%,and the gastric ulcer healing rate was 91.89%,which was higher than the control group's 75.68%,78.38%,and 72.97%,at each time point after treatment,the gastric pH values were(2.15±0.27),(3.17±0.30),(2.37±0.19),and(1.50±0.27),which were lower than(2.71±0.40),(4.01±0.42),(3.05±0.26),and(2.30±0.39)of the control group,the differences between groups were statistically significant(P＜0.05);comparison of adverse reactions between two groups,the differences was not statistically significant(P＞0.05).Conclusion Compared with standard triple therapy,sequential therapy can better clear Hp in the body of patients with Hp infected gastric ulcers,reduce gastric pH value,promote gastric ulcer healing,and do not increase adverse reactions.It is worthy of clinical promotion and application.
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