Effect of Intensity Modulated Radiotherapy and Concurrent Chemotherapy on Serum Tumor Markers and Quality of Life in Patients with Advanced Esophageal Cancer
Objective To investigate the effect of intensity modulated radiotherapy and concurrent chemotherapy in patients with advanced esophageal cancer.Methods Sixty-four patients with middle and advanced esophageal cancer admitted to Xintai People's Hospital from June 2020 to June 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method,with 32 cases in each group.Both groups received chemotherapy.On this basis,the control group received conventional radiotherapy and the observation group received intensity modulated radiotherapy.The clinical effect and safety of the two groups were compared.Results The clinical efficacy of the observation group was 93.75%,which was higher than 75.00%of control group,the difference was statistically significant(P＜0.05).After treatment,the levels of carcinoembryonic antigen,cytokeratin fragment 19 and squamous cell carcinoma antigen in the observation group were(1.61±0.27)μg/mL,(1.42±0.25)ng/mL and(1.04±0.22)μg/mL,respectively,which were lower than(1.91±0.32)μg/mL,(1.78±0.28)ng/mL and(1.38±0.25)μg/mL in the control group,and the differences between the groups were statistically significant(P＜0.05).After treatment,the scores in the tields of psychological,physiological,environmental and social relations in the World Health Organization quality of life-BREF scale for the observation groups were(86.41±6.12)points,(87.56±6.23)points,(89.47±5.81)points and(86.87±6.25)points,respectively,which were higher than(80.34±5.87)points,(80.87±6.11)points,(82.06±5.39)points and(80.76±6.14)points in the control group,and the differences between the groups were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Intensity modulated radiotherapy and concurrent chemotherapy can improve the control effect of middle and advanced esophageal cancer,reduce the level of serum tumor markers,and better improve the quality of life of patients.
Advanced esophageal cancerIntensity modulated radiotherapyChemotherapyTumor markersQuality of life
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