Therapeutic Effect of Yangxue Qingnao Granules Combined with Butylphthalide on Patients with Chronic Cerebral Circulatory Insufficiency and Its Impact on Hemorheology
Objective Observation of the therapeutic effect of Yangxue Qingnao Granules combined with butylphthalide on patients with chronic cerebral circulatory insufficiency and its impact on hemorheology.Methods A total of 72 patients with chronic cerebral ischemia admitted to Laiang Traditional Chinese Medicine Hospital of Shandong Province from May 2021 to May 2022 were selected as the research subjects,and were divided into a control group and an observation group according to random number table method,with 36 cases in each group.The control group was treated with nimodipine,while the observation group was treated with Yangxue Qingnao Granules combined with butylphthalide.Compare the clinical efficacy,hemorheological indicators,cerebral arterial blood flow velocity,endothelial function,and cognitive function between two groups.Results The total effective rate of the observation group was 94.44%,which was higher than 77.77%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,and red blood cell aggregation index in both groups were lower than those before treatment,and the observation group were lower than those of the control group,the differences were statistically significant(P<0.05);the blood flow velocity of the anterior cerebral artery,posterior cerebral artery,left and right vertebral arteries,and middle cerebral artery in both groups were faster than those before treatment,and the observation group were faster than those of the control group,the differences were statistically significant(P<0.05);the level of endothelin-1 in the observation group was lower than that in the control group,while the levels of serum nitric oxide and endothelium-deppendent dilatation were higher than those in the control group,the differences between groups were statistically significant(P<0.05);the observation group had higher scores on the Mini-Mental State Examination than the control group,the difference was statistically significant(P<0.05).Conclusion The clinical efficacy of Yangxue Qingnao Granules combined with butylphthalide in the treatment of chronic cerebral circulatory insufficiency patients is good,which can improve hemorheological indicators,cerebral artery blood flow velocity,endothelial function,and cognitive function.It is worth promoting.
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