Effects of Memantine Combined with Donepezil on Neurotransmitter and Psychological Behavioral Symptoms in Patients with Alzheimer Disease
Objective To investigate the effect of memantine combined with donepezil on patients with Alzheimer disease(AD).Methods Sixty cases of AD patients admitted to Shen County Central Hospital from September 2022 to October 2023 were selected as research objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with donepezil,and the observation group was treated with memantine hydrochloride on the basis of the control group,both groups were treated for 12 weeks.The clinical efficacy,neurotransmitter,psychological behavioral symptoms and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was higher than 70.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the average levels of 5-hydroxytryptamine,dopamine and acetylcholine in the observation group were higher than those in the control group,and the differences between the groups were statistical significance(P<0.05);the score of the Behavioral Pathology in Alzheimer's Disease rating scale in the observation group was(9.32±1.41)points,which was lower than(15.29±2.89)points in the control group,and the score of the Mini-Mental State Examination rating scale was(22.28±1.18)points,which was higher than(15.85±1.05)points in the control group,and the differences between the groups were statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Memantine combined with donepezil in the treatment of AD can effectively regulate the level of neurotransmitters in AD patients,improve the psychological behavioral symptoms of patients,and the drug is safe.
Alzheimer diseaseMemantineDonepezilNeurotransmittesPsychological and behavioral symptomsAdverse reactions
万方数据
