Effect of Budesonide,Glycopyrronium Bromide and Formoterol Fumarate Inhalation Aerosol Combined with Ambroxol on Blood Gas Analysis Indicators and Lung Function in Patients with Moderate and Severe Chronic Obstructive Pulmonary Disease
Objective To investigate the effect of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with ambroxol in patients with moderate and severe chronic obstructive pulmonary disease.Methods A total of 125 patients with moderate and severe chronic obstructive pulmonary disease admitted to People's Hospital of Jinping County from January to October 2023 were selected as the research objects,and were divided into a control group(n=62)and an observation group(n=63)according to random number table method.The control group was treated with conventional treatment,and the observation group was treated with budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with ambroxol on the basis of the control group.Blood gas analysis indicators,lung function,clinical efficacy and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.83%,which was higher than 85.48%of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of arterial partial pressure of carbon dioxide in the observation group was lower than that in the control group,and the level of arterial partial pressure of oxygen was higher than that in the control group,and the differences between the groups were statistically significant(P<0.05);the percentage of forced expiratory volume in the first second was higher than that in the control group,and the forced expiratory volume in the first second was greater than that in the control group,and the differences between the groups were statistically significant(P<0.05).Comparison of the incidence of adverse reactions between the two groups,and the differences were no statistically significant(P＞0.05).Conclusion Budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with ambroxol is effective in patients with moderate and severe chronic obstructive pulmonary disease,which can improve blood gas analysis indicators and lung function without increasing the occurrence of adverse reactions.
Moderate and severe chronic obstructive pulmonary diseaseBudesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosolAmbroxolLung functionAdverse reactions
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