Effects of Edaravone Dextrocamphorol Combined with Butylphthalein on Neurological Function and Oxidative Stress Response in Patients with Acute Cerebral Infarction
Objective To explore the effect of edaravone dextrocamphorol combined with butylphthalein in patients with acute cerebral infarction(ACI).Methods A total of 90 ACI patients admitted to Jinxiang County People's Hospital from May 2022 to May 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 45 cases in each group.The control group was treated with butylphthalein,and the observation group was treated with Edaravone dextrocamphorol combined with butylphthalein,both groups were treated for 2 weeks.The clinical efficacy,serum inflammatory factors,nerve function,oxidative stress response and occurrence of adverse reactions were compared between the two groups.Results the total effective rate of the observation group was 95.56%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of National Institutes of Health Stroke Scale score,C-reactive protein,interleukin-6 and tumor necrosis factor-α in observation group were lower than those in control group,and the differences between the groups were statistically significant(P<0.05);the levels of malondialdehyde and reactive oxygen species in observation group were lower than those in control group,and the levels of superoxide dismutase were higher than those in control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Edaravone dextrocamphorol combined with and butylphthalein has a significant effect in the treatment of ACI patients,which can regulate the level of serum inflammatory factors,promote the recovery of neurological function and improve the oxidative stress response of patients,and has a good safety.
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