Efficacy and Safety Analysis of Metoprolol Succinate Sustained Release Tablets Combined with Amiodarone in the Treatment of Patients with Coronary Heart Disease Complicated with Arrhythmia
Objective To explore the efficacy and safety of metoprolol succinate sustained release tablets combined with amiodarone in patients with coronary heart disease complicated with arrhythmia.Methods A total of 150 patients with coronary heart disease complicated with arrhythmia admitted to Jilin City Central Hospital from October 2022 to October 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 75 cases in each group.The control group was treated with amiodarone,and the observation group was treated with metoprolol succinate sustained release tablets on the basis of the control group,both groups received continuous treatment for 3 months.The clinical efficacy,cardiac function indicators,QT dispersion and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.67%,which was higher than 84.00%of the control group,and the difference was statistically significant(P<0.05).After treatment,the left ventricular ejection fraction in observation group was higher than that in control group,the left ventricular end-diastolic diameter and left ventricular end-systolic diameter were shorter than that in control group,and the differences between the groups were statistically significant(P<0.05);the corrected QT interval of the observation group was faster than that of the control group,and the QT dispersion was slower than that of the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Metoprolol succinate sustained release tablets combined with amiodarone can effectively improve cardiac function and QT dispersion in patients with coronary heart disease complicated with arrhythmia,with high safety.
万方数据
