Efficacy of Budesonide Nebulization Inhalation Combined with Azithromycin in the Treatment of Mycoplasma Pneumoniae Pneumonia in Children and its Impact on Serum Immunoglobulin Levels
Objective To investigate the effect of budesonide nebulization inhalation combined with azithromycin in the treatment of mycoplasma pneumoniae pneumonia(MPP)in children.Methods Ninety-two children with MPP treated in the Second People's Hospital of Guiyang City from April 2021 to December 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 46 cases in each group.The control group was treated with azithromycin,and the observation group was treated with budesonide nebulization inhalation.The control group received azithromycin,while the observation group received budesonide nebulized inhalation.The clinical efficacy,serum immunoglobulin levels,inflammatory indicators and safety of the two groups were compared.Results The total effective rate of the observation group was 95.65%,which was higher than 82.61%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of immunoglobulin M,immunoglobulin A and immunoglobulin G in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);the levels of C-reactive protein,white blood cell count and procalcitonin in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Budesonide nebulization inhalation combined with azithromycin can enhance the therapeutic effect of MPP,improve the level of serum immunoglobulin,reduce inflammation,promote the outcome of the disease,and is safe and effective.
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