Effect of Piperacillin Sulbactam Combined with Methylprednisolone on Inflammatory Factors Levels and Pulmonary Function Recovery in Patients with Severe Pneumonia
Objective To investigate the effect of piperacillin and sulbactam combined with methylprednisolone in the treatment of severe pneumonia.Methods Clinical data of 84 patients with severe pneumonia admitted to Linyi Central Hospital from April 2021 to May 2023 were retrospectively analyzed.According to different treatment methods,they were divided into a control group and an observation group,with 42 cases in each group.The control group was treated with piperacillin and sulbactam,and the observation group was treated with piperacillin and sulbactam combined with methylprednisolone,both groups received continuous treatment for 1 week.The clinical efficacy,inflammatory factors,recovery of pulmonary function and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.24%,which was higher than 80.95%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α,interleukin-6 and interleukin-10 in the observation group were(0.88±0.21)ng/mL,(28.42±6.74)pg/mL and(2.26±0.51)pg/mL,respectively,which were lower than(1.33±0.29)ng/mL,(38.39±9.17)pg/mL,(3.52±0.73)pg/mL in the control group,and the differences between the groups were statistically significant(P<0.05);the forced vital capacity and forced expiratory volume of the first second in the observation group were(86.85±9.25)L and(85.89±7.46)L,respectively,which were higher than(80.86±8.35)L and(80.33±7.12)L in the control group,and the peak expiratory flow rate was(80.85±9.05)L/min,which was faster than(72.89±8.87)L/min of control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of piperacillin and sulbactam combined with methylprednisolone in the treatment of severe pneumonia has a remarkable effect,can effectively reduce the level of inflammatory factors,improve Pulmonary function,and has a good application safety.
Severe pneumoniaPiperacillin sulbactamMethylprednisoloneInflammatory factorsPulmonary functionClinical efficacy
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