Effect of Xipayi Gingival Consolidation Fluid Combined with Minocycline Hydrochloride Ointment on Patients with Chronic Periodontitis
Objective To investigate the effect of sipayi gingival solidifying fluid combined with minocycline hydrochloride ointment on patients with chronic periodontitis(CP).Methods Sixty patients with CP admitted to Jining Third People's Hospital(Yanzhou District People's Hospital)from October 2021 to October 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with minocycline hydrochloride ointment,and the observation group was treated with sipayi gingival consolidation fluid on the basis of the control group,both groups were treated continuously for 4 weeks.The levels of gingival creval fluid inflammatory factors,oxidative stress indicators,periodontal indicators,occurrence of adverse reactions and recurrence situation were compared between the two groups.Results After treatment,tumor necrosis factor-α,high-sensitive C-reactive protein,interleukin-6,plaque index,probing depth,adhesion level and bleeding index in the observation group were lower than those in the control group,glutathione peroxidase and superoxide dismutase were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate in the observation group was 3.33%,which was lower than 26.67%in the control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of CP patients,the combination of cipayi gingival solid solution and minocycline hydrochloride ointment can effectively improve periodontal indexes,reduce oxidative stress and inflammation,and reduce the recurrence rate,and the drug is safe.
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