Effect of Combination Therapy with Carilizumab and Chemotherapy on Tumor Markers and T Cell Factor in Patients with Advanced Gastric Cancer
Objective To investigate the effect of camrelizumab combined with chemotherapy in the treatment of advanced gastric cancer.Methods A total of 102 patients with advanced gastric cancer admitted to the Affiliated Hospital of Xuzhou Medical University from June 2022 to December 2023 were selected as the research objects,according to the random number table method,they were divided into a control group and an observation group,with 51 cases in each group.The control group was treated with conventional chemotherapy,and the observation group was treated with camrelizumab on the basis of the control group.The clinical efficacy,tumor markers,T cell factor and adverse reactions were compared between the two groups.Results The disease control rate of the observation group was 92.16%,which was higher than 76.47%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of carbohydrate antigen 199,carcinoembryonic antigen and carbohydrate antigen 724 in the observation group were(32.96±3.52)U/mL,(26.63±2.42)ng/mL and(24.63±2.12)U/mL,respectively,which were lower than(37.28±3.76)U/mL,(31.57±3.69)ng/mL,(28.96±2.43)U/mL of the control group,the differences between the groups were statistically significant(P<0.05);the levels of interleukin-6 and interleukin-8 in the observation group were(17.58±1.32)pg/mL and(5.63±1.12)pg/mL,respectively,which were lower than(19.57±1.34)pg/mL and(7.89±1.14)pg/mL in the control group,the level of interferon-γ was(10.69±1.25)pg/mL,which was higher than(9.15±1.17)pg/mL in the control group,and the differencse between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Camrelizumab combined with chemotherapy can better control the condition of advanced gastric cancer,reduce the levels of tumor markers,improve the activity of T cell factor,and does not increase the risk of adverse reactions.
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