Observation of the Efficacy of Peramivir Combined with Cefotaxime in the Treatment of Influenza Virus Pneumonia Patients
Objective Exploring the clinical efficacy of peramivir combined with cefotaxime in the treatment of influenza virus pneumonia patients.Methods A total of 78 patients with influenza virus pneumonia admitted to Rizhao Central Hospital from June 2020 to June 2023 were selected as the research subjects,according to the random number table method,they were divided into a control group and an observation group,with 39 cases in each group.The control group was treated with cefotaxime,while the observation group was treated with combination therapy with peramivir on the basis of the control group,both groups were treated continuously for 3 days.Compare the clinical efficacy,disappearance time of clinical symptoms,inflammatory response,and occurrence of adverse reactions between two groups.Results The total effective rate of the observation group was 94.87%,which was higher than 79.49%of the control group,the difference was statistically significant(P<0.05).The disappearance time of cough,fever,sore throat,and runny nose in the observation group were shorter than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of C-reactive protein,tumor necrosis factor-α,intercellular adhesion molecule-1,and interleukin-6 in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).Comparison of incidence of adverse reactions between two groups,the difference was not statistically significant(P＞0.05).Conclusion Peramivir combined with cefotaxime can effectively alleviate clinical symptoms and inflammatory reactions in patients with influenza virus pneumonia,and has high safety.
万方数据
