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丁苯酞联合氯吡格雷治疗对急性脑梗塞患者的效果

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目的 探讨丁苯酞联合氯呲格雷治疗对急性脑梗塞患者的具体效果.方法 选择 2022 年 9 月—2023 年 10月郓城县中医医院收治的 84 例急性脑梗塞患者为研究对象,按随机数字表法将其分为对照组和观察组,各 42 例.对照组采用氯呲格雷治疗,观察组在对照组的基础上采用丁苯酞注射液治疗.比较两组患者的临床疗效、神经功能、炎症反应指标及不良反应发生情况.结果 观察组治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05).治疗前,两组美国国立卫生研究院卒中量表(NHISS)评分对比,差异无统计学意义(P>0.05);治疗后,观察组NHISS评分低于对照组,差异有统计学意义(P<0.05).治疗前,两组炎症反应指标对比,差异无统计学意义(P>0.05);治疗后,观察组超敏C反应蛋白、肿瘤坏死因子-α及白细胞介素-6 均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论 丁苯酞联合氯呲格雷治疗急性脑梗塞的效果确切,可改善神经功能,减轻机体的炎症反应,且安全性良好.
Effect of Butylphthalein Combined with Clopidogrel on Patients with Acute Cerebral Infarction
Objective Objective To investigate the specific effect of butylphthalein combined with clophagrel on patients with acute cerebral infarction.Methods A total of 84 patients with acute cerebral infarction treated in Yuncheng County Traditional Chinese Medicine Hospital from September 2022 to October 2023 were selected as the research objects,they were divided into a control group and an observation group according to random number table method,with 42 cases in each group.The control group was treated with clobgrel,and the observation group was treated with butylphthalein injection on the basis of the control group.The clinical efficacy,neurological function,inflammatory response indicators and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.24%,which was higher than 80.95%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in National Institutes of Health Stroke Scale(NHISS)score between the two groups(P>0.05);after treatment,NHISS score in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in inflammatory response indicators between the two groups(P>0.05);after treatment,hypersensitive C-reactive protein,tumor necrosis factor-α and interleukin-6 in the observation group were lower than those in the control group,and the differences between the groups were statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The effect of butylphthalein combined with clophagrel in the treatment of acute cerebral infarction is accurate,can improve nerve function,reduce inflammatory response,and has good safety.

Acute cerebral infarctionButylphthaleinClopidogrelClinical efficacyNeurological functionInflammatory response

冯黎明

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郓城县中医医院脑病二科,山东 菏泽 274000

急性脑梗塞 丁苯酞 氯呲格雷 临床疗效 神经功能 炎症反应

2024

反射疗法与康复医学

反射疗法与康复医学

ISSN:
年,卷(期):2024.5(14)