Effect of Low Molecular Weight Heparin Sodium Combined with Nifedipine in the Treatment of Hypertensive Patients during Pregnancy
Objective To investigate the effect of low molecular weight heparin sodium combined with nifedipine(NIF)in the treatment of gestational hypertension(HDCP).Methods Sixty patients with HDCP treated in Jinxiang County People's Hospital of Jining City,Shandong Province from July 2019 to July 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with NIF,and the observation group was treated with low molecular weight heparin sodium on the basis of the control group,and both groups were treated for 14 consecutive days.The clinical efficacy,blood pressure level,uterine arterial hemodynamics and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.33%,which was higher than 73.33%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood pressure and uterine arterial hemodynamics between the two groups(P＞0.05);after 14 days of treatment,the diastolic blood pressure,systolic blood pressure,umbilical artery pulse index and resistance index,and the ratio of maximum blood flow velocity to end-diastolic blood flow velocity in the observation group were lower than those in the control group,and the differences between the groups were statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion In HDCP patients,low molecular weight heparin sodium combined with NIF has a significant effect,which can effectively regulate blood pressure and improve uterine artery blood flow,and the drug is safe.
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