Effect of Saccharomyces Boulardii Sachets Combined with Mesalazine Enteric Coated Tablets on Symptom Improvement Time and Intestinal Mucosal Inflammatory Factor Levels in Patients with Ulcerative Colitis
Objective Exploring the effect of combination therapy of saccharomyces boulardii sachets and mesalazine enteric coated tablets on symptom improvement time and intestinal mucosal inflammatory factor levels in patients with ulcerative colitis(UC).Methods Selecting 60 UC patients admitted to Weishan County People's Hospital from December 2021 to October 2023 as the research subjects,using a random number table method,they were divided into a control group and an observation group,with 30 cases in each group.The control group was treated with mesalazine enteric coated tablets,while the observation group was treated with combination therapy of saccharomyces boulardii sachets on the basis of the control group.Compare the clinical efficacy,symptom improvement time,levels of intestinal inflammatory factors,levels of gut microbiota,and incidence of adverse reactions between two groups.Results The total effective rate of the observation group was 90.00%,which was higher than 63.33%of the control group,the difference was statistically significant(P<0.05);the improvement time of purulent and bloody stool,diarrhea,and severe diarrhea in the observation group were shorter than those of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α and interleukin-6 in the observation group were lower than those in the control group,the differences between the groups were statistically significant(P<0.05);the level of beneficial bacteria in the observation group was higher than that in the control group,while the levels of neutral and harmful bacteria were lower than those in the control group,the differences between groups were statistically significant(P<0.05).Comparison of incidence of adverse reactions between two groups,the difference was not statistically significant(P＞0.05).Conclusion The use of saccharomyces boulardii sachets combined with mesalazine enteric coated tablets in the treatment of UC patients has a significant effect,which can significantly improve discomfort symptoms,reduce inflammatory reactions,regulate intestinal microbiota,and ensure medication safety.
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