Effect of Zhigancao Decoction Combined with Esmolol in the Treatment of Ventricular Arrhythmia with Qi and Yin Deficiency Syndrome and Its Influence on Patients' Cardiac Function and Myocardial Damage Markers
Objective To investigate the effects of Zhigancao Decoction combined with esmolol on cardiac function and myocardial damage markers in patients with ventricular arrhythmia with Qi and Yin deficiency syndrome.Methods A total of 180 patients with ventricular arrhythmias with Qi and Yin deficiency syndrome admitted to Yicheng District Hospital of Traditional Chinese Medicine in Zaozhuang City from January 2020 to January 2022 were selected as the research objects, they were divided into a control group and an observation group according to random number table method, with 90 cases in each group.The control group was treated with esmolol, on the basis of which, the observation group was treated with Zhigancao Decoction.The clinical efficacy, cardiac function, myocardial damage markers and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 88.89％, which was higher than 71.11％ of the control group, the difference was statistically significant (P<0.05).Before treatment, there was no significant difference in the level of cardiac function indexes between the two groups (P>0.05);after treatment, the left ventricular ejection fraction, stroke volume and cardiac output of the observation group were (74.92±4.25)％, (72.46± 3.17)mL and (4.48±0.36)L/min, all higher than those of the control group, and the left ventricular end-systolic diameter was (41.33±1.76)mm, shorter than that of the control group, the differences between the groups were statistically significant (P<0.05).Before treatment, there was no significant difference in the levels of myocardial injury markers between the two groups (P>0.05);after treatment, the levels of creatine kinase-MB, cardiac troponin T and N terminal pro B type natriuretic peptide in the observation group were (15.32±1.25)U/L, (0.12±0.02)μg/L and (271.53±14.25)pg/mL, respectively, which were lower than those of the control group, and the differences between the groups were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion Zhigancao Decoction combined with esmolol is effective in the treatment of patients with ventricular arrhythmia with Qi and Yin deficiency syndrome, which can effectively improve their heart function, reduce the level of myocardial damage markers, reduce myocardial injury, and is relatively safe.
Ventricular arrhythmiaQi and Yin deficiency syndromeZhigancao DecoctionEsmololCardiac functionMyocardial damage makers
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