Efficacy and Safety Analysis of Budesonide Inhalation Aerosol Combined with Acetylcysteine in the Treatment of AECOPD
Objective To investigate the efficacy and safety of budesonide inhalation aerosol combined with acetylcysteine in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods A total of 80 patients with AECOPD admitted to Tengzhou Traditional Chinese Medicine Hospital from June 2021 to June 2023 were selected as the research objects and were divided into a control group and an observation group according to random number table method, with 40 cases in each group.The control group was treated with budesonide inhalation aerosol, and the observation group was treated with acetylcysteine effervescent tablets.Both groups were treated for 10 days.The clinical efficacy, lung function, blood gas indexes, inflammatory response and safety of the two groups were compared.Results The total effective rate of the observation group was 95.00％, higher than 80.00％of the control group, the difference was statistically significant (P<0.05).After treatment, the forced vital capacity and forced expiratory volume in one second in the observation group were higher than those in the control group, and the differences between the groups were statistically significant (P<0.05).After treatment, the blood oxygen partial pressure of the observation group was higher than that of the control group, and the carbon dioxide partial pressure was lower than that of the control group, and the differences between the groups were statistically significant (P<0.05).After treatment, the levels of procalcitonin, hypersensitive C-reactive protein and tumor necrosis factor-α in the observation group were lower than those in the control group, and the differences between the groups were statistically significant (P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion The treatment of AECOPD with budesonide inhalation aerosol combined with acetylcysteine can reduce the inflammatory response of patients, regulate the blood gas indexes, and accelerate the improvement of lung function.It is safe and reliable, and worthy of clinical promotion.
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