Effect of Pulmonary Surfactant Combined with Bi-Level Positive Airway Pressure Support on Respiratory Mechanics and Blood Gas Indicators in Newborns with Respiratory Distress Syndrome
Objective To explore the effect of combined treatment with bi-level positive airway pressure (BiPAP) and pulmonary surfactant (PS) in neonates with respiratory distress syndrome (NRDS).Methods A total of 80 children with NRDS admitted to Tengzhou Central People's Hospital from January 2021 to September 2023 were selected as the research subjects.They were randomly divided into a control group and an observation group using a random number table method, with 40 cases in each group.The control group received BiPAP treatment, and based on this, the observation group received PS.The respiratory mechanics, blood gas, and complications of the two groups were compared.Results After assisted ventilation, the tidal volume of the observation group was greater than that of the control group, and the oxygenation index and lung dynamic compliance were higher than those of the control group, the inspiratory resistance was lower than that of the control group, and the differences between the groups were statistically significant (P<0.05).After assisted ventilation, the oxygen partial pressure and pH level in the observation group were higher than those in the control group, while the carbon dioxide partial pressure was lower than those in the control group, the differences between the groups were statistically significant (P<0.05).The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).Conclusion The combination of PS and BiPAP treatment for NRDS newborns can improve respiratory mechanics and blood gas indicators, and reduce the risk of complications.
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