Efficacy and Safety of Edaravone and Dextrocamphorol Concentrated Solution for Injection Combined with Butylphthalein and Sodium Chloride Injection in the Treatment of Acute Cerebral Infarction
Objective To investigate the therapeutic effect of edaravone and dextrocampbodol concentrated solution for injection and butylphthalide and sodium chloride injection on acute cerebral infarction.Methods A total of 68 patients with acute cerebral infarction admitted to Shandong Rongjun General Hospital from January 2021 to October 2023 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 34 cases in each group.The control group was treated with butylphthalide and sodium chloride,and the observation group was treated with edaravone dexborneol on the basis of the control group.The clinical efficacy,nerve function,hemorheology,vascular endothelial function and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.12%,which was higher than 76.47%of the control group,the difference was statistically significant(P＜0.05).After treatment,the National Institutes of Health Stroke Scale score,high blood viscosity,low blood viscosity,plasma viscosity and endothelin-1 level in the observation group were lower than those in the control group,and the level of nitric oxide was higher than that in the control group,the differences between the two groups were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Edaravone and dextrocamphorol combined with butylphthalide is effective in the treatment of acute cerebral infarction,which can improve the neurological function and hemorheology index,reduce vascular endothelial injury,and has high safety.
Acute cerebral infarctionEdaravone and dextrocamphorolButylphthalideNeurological functionHemorhe-ologyVascular endothelial function
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