首页|胫骨横向骨搬移术治疗对糖尿病足患者血清炎性因子及溃疡愈合的影响

胫骨横向骨搬移术治疗对糖尿病足患者血清炎性因子及溃疡愈合的影响

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目的 探讨胫骨横向骨搬移术(TTT)在糖尿病足(DF)患者中的应用效果.方法 选取2020年6月—2023年6 月聊城市中医医院收治的 80 例DF患者为研究对象,按随机数字表法将其分为对照组及观察组,每组 40 例.对照组采用常规治疗,观察组在此基础上采用TTT治疗.比较两组患者的临床疗效、血清炎性因子水平、溃疡愈合时间、踝肱指数及生活质量.结果 观察组的治疗总有效率为 95.00%,高于对照组的 80.00%,差异有统计学意义(P<0.05).治疗 3 个月后,观察组的C反应蛋白、白细胞介素-6、降钙素原水平分别为(4.81±0.47)mg/L、(3.35±0.32)ng/L、(0.51±0.11)μg/L,均低于对照组的(6.02±1.03)mg/L、(4.27±0.45)ng/L、(0.79±0.14)μg/L,组间差异有统计学意义(P<0.05).观察组的溃疡愈合时间为(2.32±0.36)个月,短于对照组的(3.12±0.41)个月,差异有统计学意义(P<0.05).治疗 3 个月后,观察组的踝肱指数为(0.96±0.16),高于对照组的(0.81±0.14),差异有统计学意义(P<0.05).治疗 3 个月后,观察组的世界卫生组织生活质量评定量表简表中生理、心理、社会、环境评分分别为(87.53±5.19)分、(85.58±5.14)分、(88.31±5.25)分、(90.65±4.29)分,均高于对照组的(79.84±5.05)分、(78.35±5.09)分、(80.64±5.15)分、(83.75±5.05)分,组间差异有统计学意义(P<0.05).结论 TTT治疗DF的效果理想,可加速溃疡愈合,降低炎性因子水平,促进踝肱指数恢复,改善患者生活质量.
Effect of Tibial Transverse Transport on Serum Inflammatory Factors and Ulcer Healing in Patients with Diabetic Foot
Objective To investigate the effect of tibial transverse transport(TTT)in patients with diabetic foot(DF).Methods A total of 80 cases of DF patients admitted to Liaocheng Hospital of Traditional Chinese Medicine from June 2020 to June 2023 were selected as the study objects and were divided into a control group and an observation group according to random number table method,with 40 cases in each group.The control group received conventional treatment,and the observation group received TTT treatment on this basis.The clinical efficacy,serum inflammatory factor levels,ulcer healing time,ankle-brachial index and quality of life were compared between the two groups.Results The total effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).After 3 months of treatment,the levels of C-reactive protein,interleukin-6 and procalcitonin in the observation group were(4.81±0.47)mg/L,(3.35±0.32)ng/L and(0.51±0.11)μg/L,respectively,which were lower than(6.02±1.03)mg/L,(4.27±0.45)ng/L,(0.79±0.14)μg/L in the control group,the differences between the groups were statistically significant(P<0.05).The healing time of ulcer in the observation group was(2.32±0.36)months,which was shorter than(3.12±0.41)months in the control group,the difference was statistically significant(P<0.05).After 3 months of treatment,the ankle-brachial index of the observation group was(0.96±0.16),which was higher than(0.81±0.14)of the control group,the difference was statistically significant(P<0.05).After 3 months of treatment,the physiological,psychological,social and environmental scores of the World Health Organization Quality of Life-BREF scale in the observation group were(87.53±5.19)points,(85.58±5.14)points,(88.31±5.25)points and(90.65±4.29)points,respectively,which were higher than(79.84±5.05)points,(78.35±5.09)points,(80.64±5.15)points and(83.75±5.05)points in the control group,the differences between the groups were statistically significant(P<0.05).Conclusion TTT is effective in treating DF.It can speed up ulcer healing,reduce inflammatory factors,promote ankle-brachial index recovery and improve patients'quality of life.

Diabetic footTibial transverse transportSerum inflammatory factorsUlcer healing

杨法报、王云霞、崔静

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聊城市中医医院手足外科,山东聊城 252000

聊城市东昌府区张炉集镇中心卫生院全科,山东聊城 252000

聊城运东医院检验科,山东聊城 252000

糖尿病足 胫骨横向骨搬移术 血清炎性因子 溃疡愈合

2024

反射疗法与康复医学

反射疗法与康复医学

ISSN:
年,卷(期):2024.5(16)
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