Clinical Effect of Olanzapine Combined with Magnesium Valproate Sustained-Release Tablets in the Treatment of Positive Symptoms in Schizophrenia Patients
Objective To investigate the clinical effect of olanzapine combined with magnesium valproate sustained-release tablets in the treatment of positive symptoms in schizophrenia patients.Methods A total of 100 patients with schizophrenia admitted to the Qufu Psychiatric Hospital of Shandong Province from June 2021 to June 2023 were selected as the study objects and randomly divided into a control group and a study group according to random number table method,with 50 cases in each group.The control group was treated with olanzapine,and the study group was treated with olanzapine combined with magnesium valproate sustained-release tablets.The mental injury status,therapeutic effect,occurrence of adverse reactions and quality of life were compared between the two groups.Results Before treatment,there was no significant difference in positive symptom score of the Postive and Negative Symptom Scale(PANSS)between the two groups(P＜0.05);after 2 months of treatment,the PANSS positive symptom score of the study group was(10.12±2.04)points,which was lower than(15.17±1.89)points of the control group,the difference was statistically significant(P＜0.05).The total effective rate of the study group was 96.00%,which was higher than 84.00%of the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＜0.05).Before treatment,there were no significant differences between the two groups in all dimension scores of the generic quality of life inventory-74(P＞0.05);after 2 months of treatment,the scores of psychological function,social function,state of material life and physical function of the study group were(72.56±6.12)points,(70.18±6.24)points,(74.57±5.23)points and(75.37±5.47)points,respectively,which were higher than(64.35±4.23)points,(58.12±4.18)points,(66.42±4.26)points,(69.12±3.28)points in the control group,the differences between the groups were statistically significant(P＜0.05).Conclusion The effect of olanzapine combined with magnesium valproate sustained-release tablets in the treatment of schizophrenia is ideal,can significantly improve the positive symptoms and quality of life,and the adverse reactions are less,which is worthy of clinical promotion.
SchizophreniaOlanzapineMagnesium valproate sustained-release tabletsPositive symptomsClinical efficacyQuality of life
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