Comparison of the Clinical Effect of Escitalopram and Paroxetine in the Treatment of Elderly Patients with Depression
Objective To investigate the effect of escitalopram and paroxetine in the treatment of senile depression.Methods A total of 64 elderly patients with depression admitted to our hospital from March 2020 to October 2023 were selected as the research objects,and they were divided into a control group and an observation group according to the random number table method,with 32 cases in each group.The control group was treated with paroxetine,and the observation group was treated with escitalopram for 12 weeks.The clinical efficacy,Hamilton Depression Scale(HAMD)score,Pittsburgh Sleep Quality Index(PSQI)score,brain nerve factors,quality of life and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the HAMD score and PSQI score of the observation group were(13.58±1.38)points and(5.34±1.03)points,respectively,which were lower than(16.82±1.54)points and(7.67±1.12)points of the control group,the differences were statistically significant(P＜0.05);the levels of serotonin and brain-derived neurotrophic factor in the observation group were(290.29±25.47)μg/L and(28.74±2.65)ng/L,respectively,which were higher than(265.74±24.18)μg/L and(23.85±2.57)ng/L in the control group,the level of neuron-specific enolase was(5.89±1.05)ng/mL,which was lower than(7.75±1.12)ng/mL in the control group,the differences between the two groups were statistically significant(P＜0.05);the The World Health Organization Quality of Life-BREF scores of the observation group were(86.57±5.24)points,(87.41±5.32)points,(88.74±5.34)points and(90.41±4.35)points,respectively,the scores were higher than(79.63±5.19)points,(80.57±5.28)points,(82.04±5.29)points,(83.14±4.82)points of the control group,the differences between the two groups were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Escitalopram is more effective in the treatment of senile depression,which can speed up the disappearance of depression,reduce sleep disorders,reduce the impact of disease on life,and is safe and reliable.
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