Clinical Effect of Budesonide Formoterol Powder Combined with Tiotropium Bromide Powder in the Treatment of Chronic Obstructive Pulmonary Disease
Objective To investigate the effect of budesonide formoterol powder combined with tiotropium bromide powder on patients with chronic obstructive pulmonary disease(COPD)in stable stage.Methods A total of 84 patients with COPD in stable stage admitted to the Gangcheng District People's Hospital from October 2022 to October 2023 were selected as the research objects and were randomly divided into a control group and a research group,with 42 cases in each group.The control group was treated with tiotropium bromide powder,and the research group was treated with budesonide formoterol powder and tiotropium bromide powder.The levels of inflammatory factors,blood gas indexes,lung function indexes,treatment effectiveness and incidence of adverse reactions were compared between the two groups.Results After 30 days of treatment,the levels of interleukin-6,C-reactive protein and procalcitonin in the research group were(15.24±2.34)pg/mL,(10.23±2.08)mg/L and(4.12±0.31)ng/mL,respectively,which were lower than(18.65±3.48)pg/mL,(14.56±2.37)mg/L,(5.78±0.32)ng/mL in control group,and the differences between the groups were statistically significant(P＜0.05).After 30 days of treatment,the blood oxygen partial pressure of the research group was(82.56±4.38)mmHg,higher than(74.35±5.12)mmHg of the control group,and the blood carbon dioxide partial pressure was(50.45±3.12)mmHg,lower than(58.23±2.68)mmHg of the control group,the differences between the groups were statistically significant(P＜0.05).After 30 days of treatment,the forced vital capacity(FVC),forced expiratory volume(FEV1)and FEV1/FVC of the research group were(2.78±0.54)L,(1.96±0.47)L and(80.45±4.32)%,respectively,which were greater than(1.85±0.83)L,(1.52±0.54)mL and(74.16±4.28)%in the control group,and the differences between the groups were statistically significant(P＜0.05).The total effective rate of the research group was 97.62%,which was higher than 80.95%of the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Budesonide formoterol powder combined with tiotropium bromide powder has an ideal effect in the treatment of COPD,which can significantly reduce the inflammatory response of patients,improve the blood gas indexes and lung function,and have fewer adverse reactions,so it has high application value.
NETL
NSTL
万方数据
