Therapeutic Effect of Domperidone Combined with Pinaverium Bromide and Itopride Hydrochloride Dispersible Tablets in the Treatment of Elderly Functional Dyspepsia and Its Impact on the Time of Symptom Disappearance
Objective To observe the therapeutic effect of domperidone combined with pinaverium bromide and itopride hydrochloride dispersible tablets in the treatment of elderly functional dyspepsia.Methods A total of 82 elderly patients with functional dyspepsia admitted to Yicheng District People's Hospital in Zaozhuang City from June 2020 to June 2023 were selected as the research subjects,divided into a control group and an observation group according a random number table method,with 41 cases in each group.The control group was treated with pinaverium bromide and itopride hydrochloride dispersible tablets,while the observation group was treated with a combination of domperidone in addition to the control group.The clinical efficacy,symptom disappearance time,gastrointestinal hormone levels,and the occurrence adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 92.68%,higher than the control group's 73.17%,the difference was statistically significant(P＜0.05).After treatment,the disappearance time of symptoms such as loss of appetite,bloating,upper abdominal pain,and early satiety in the observation group were shorter than those in the control group,the differences between groups were statistically significant(P＜0.05);the levels of gastrin-17 and motilin in the observation group were(11.76±1.42)μmol/L and(291.44±25.68)pg/mL,both higher than(8.82±1.14)μmol/L and(248.60±21.57)pg/mL in the control group,and the levels of vasoactive intestinal peptide was(11.37±1.69)pg/mL and lower than(16.40±2.07)pg/mL in the control group,respectively,the differences between groups were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two group(P＞0.05).Conclusion The domperidone combined with pinaverium bromide and itopride hydrochloride dispersible tablets has a definite effect on the treatment of functional dyspepsia in the elderly.It can accelerate the disappearance of symptoms in patients,regulate gastrointestinal hormone levels,and is safe and reliable.
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