Effect of Labetalol Combined with Magnesium Sulfate Injection on Patients with Pregnancy Induced Hypertension
Objective To investigate the effect of labetalol combined with magnesium sulfate injection on patients with pregnancy induced hypertension(PIH).Methods A total of 70 patients with PIH treated in Juxian People's Hospital from February 2021 to February 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 35 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with hydrochloride labetalol on the basis of the control group,and the two groups were continued to take medication until the patient gave birth.The clinical efficacy,blood pressure control,physiological indexes,pregnancy outcome of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was 97.14%,which was higher than 74.29%of the control group,the difference was statistically significant(P＜0.05).After treatment,the diastolic blood pressure and systolic blood pressure of the observation group were(84.32±9.11)mmHg and(132.68±8.16)mmHg,respectively,which were lower than(90.71±8.03)mmHg and(142.09±9.31)mmHg of the control group,the differences were statistically significant between the two groups(P＜0.05);24 h urinary protein,interleukin-6 and homocysteine in the observation group were(1.25±0.24)g,(22.17±3.34)pg/mL and(11.15±1.07)μmol/L,respectively,which were lower than(1.89±0.81)g,(30.15±4.26)pg/mL and(13.44±1.21)umol/L in the control group,the differences between the two groups were statistically significant(P＜0.05).The incidence of adverse pregnancy outcome in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05);there was no significant difference in the incidence adverse reactions between the two groups(P＞0.05).Conclusion The labetalol combined with magnesium sulfate injection in treatment of patie nts with PIH is effective,can effectively improve the blood pressure level of patients,adjust the physiological indicators of patients,reduce the risk of adverse pregnancy outcomes,and has a certain safety.
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