Clinical Efficacy of Nicodil Combined with Nitrates in the Treatment of Microvascular Angina Pectoris and Its Influence on the Onset of Angina Pectoris
Objective To investigate the effect of combination of nicodil and nitrates in the treatment of microvascular angina pectoris.Methods A total of 84 patients with microvascular angina pectoris treated in our hospital from June 2021 to June 2023 were selected as the study objects,and randomly divided into a control group and an observation groupaccording to random number table method,with 42 cases in each group.The control group was treated with isosorbide mononitrate,and the observation group was treated with nicodil on the basis of the control group and both groups were treated for 8 weeks.The clinical efficacy,angina pectoris attack,vascular endothelial function,electrocardiog index and safety of the two groups were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the frequency of angina pectoris attacks in the observation group was(3.44±0.42)times/week,which was less than(5.37±0.85)times/week in the control group,and the duration was(2.04±0.28)min,which was shorter than(3.65±0.37)min in the control group,the differences between the groups were statistically significant(P＜0.05);the level of nitric oxide in the observation group was(46.89±4.25)μmol/L,higher than(41.33±4.15)μmol/L in the control group,and the level of endothelin-1 was(40.15±4.12)ng/L,endothelin-1 which was lower than(46.38±4.37)ng/L in the control group,the differences between the groups were statistically significant(P＜0.05);the total motion time and ST segment depression 0.1 mV in the observation group were(8.96±0.87)min and(7.46±0.75)min,respectively,which were both longer than(6.85±0.79)min and(5.87±0.67)min in the control group,the maximum ST segment depression was(0.54±0.11)mV,which was lower than(0.78±0.13)mV of control group,and the differences between the groups were statistically significant(P＜0.05).No obvious adverse reactions occurred in both groups.Conclusion Nicordil combined with nitrates can improve the efficacy of microvascular angina pectoris,relieve vascular endothelial dysfunction,reduce angina pectoris attack,and is safe and reliable.
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