Observation of the Therapeutic Effect of the Combination of Sacubitril Valsartan and Metoprolol in Elderly Patients with Coronary Heart Disease and Heart Failure
Objective Exploring the efficacy of the combination of sacubitril valsartan and metoprolol in the treatment of elderly patients with coronary heart disease and heart failure(HF).Methods Selecting 120 elderly patients with coronary HF admitted to Jinan Beicheng Hospital from January to December 2023 as the research subjects,according to the random number table method,they were divided into an observation group and a control group,with 60 cases in each group.Both groups received routine treatment upon admission,with the control group receiving oral metoprolol and the observation group receiving a combination of sacubitril valsartan on the basis of the control group.The clinical efficacy,cardiac function indicators,levels of neuroendocrine factors and the occurrence adverse reaction were Compared between two groups of patients.Results The total effective rate of the observation group was 90.33%,which was higher than the control group's 70.00%,the difference was statistically significant(P＜0.05).After 3 months of treatment,the levels of left ventricular end systolic diameter and left ventricular end diastolic diameter in both groups were shorter than before treatment,and the observation group were shorter than those in the control group,the difference was statistically significant(P＜0.05);the left ventricular ejection fraction in both groups were higher than before treatment,and the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05);the levels of N-terminal pro-brain natriuretic peptid,aldosterone,and AngiotensinⅡin both groups were lower than before treatment,and the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).Comparison of incidence of adverse reactions between two groups,the difference was not statistically significant(P＞0.05).Conclusion The combination of sacubitril valsartan with metoprolol has a definite effect on the treatment of elderly patients with coronary heart disease and HF,it can improve the patient's heart function,regulate the level of neuroendocrine factors,and has high safety.
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