Effect of the Combination Therapy of Musk Heart Protecting Pill and Sacubitril Valsartan on Cardiac Function and Inflammatory Indicators in Patients with Chronic Heart Failure
Objective To investigate the effect of Musk Heart Protecting Pill combined with Sacubitril Valsartan on cardiac function and inflammatory indicators in patients with chronic heart failure (CHF). Methods 100 CHF patients admitted to Jinxiang County People's Hospital from January 2022 to June 2023 were selected as the research subjects,they were randomly divided into a control group and an observation group,with 50 patients in each group,using a random number table method. The control group was treated with Sacubitril Valsartan,while the observation group was treated with Sacubitril Valsartan combined with Musk Heart Protecting Pill. Compare the clinical efficacy,cardiac function indicators,inflammation indicators,and adverse reactions between two groups. Results The total effective rate of the observation group was 96.00％,which was higher than 84.00％ of the control group,and the difference was statistically significant (P<0.05). After treatment,the left ventricular ejection fraction (42.17±3.72)％ and cardiac output (6.16±1.06)L/min in the observation group were higher than those in the control group,the left ventricular end diastolic diameter (57.45±3.68)mm and left ventricular end systolic diameter (41.12±5.48) mm were shorter than those in the control group,the levels of interleukin-6 (121.39±18.06)ng/L,C-reactive protein (24.34±5.13) mg/L,and tumor necrosis factor-a (105.27±15.44)pg/mL were all lower than those in the control group,and the differences between the groups were statistically significant (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The combination of Musk Heart Protecting Pill and Sacubitril Valsartan has a significant effect on the treatment of CHF,which can improve patients' cardiac function,reduce cardiac inflammatory indicators,and is relatively safe.
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