Effect of Ginkgo Leaf Extract and Dipyridamole combined with Edaravone Injection on Hemorheological Indicators and Oxidative Stress Response in Patients with Acute Cerebral Infarction
Objective To investigate the effects of ginkgo leaf extract and dipyridamole combined with edaravone injection on hemorheological indicators and oxidative stress response in patients with acute cerebral infarction (ACI). Methods Seventy-Eight patients with ACI admitted to the Encephalopathy Department of Hospital of Tengzhou Traditional Chinese Medicine from August 2020 to August 2023 were selected as the research objects,and were divided into a control group and an observation group by random number table method,with 39 cases in each group. The control group was treated with edaravone injection,the observation group was treated with ginkgo leaf extract and dipyridamole on the basis of the control group. Both groups were treated for 2 weeks. The hemorheological indicator levels,oxidative stress response,neurological function and occurrence of adverse reactions were compared between the two groups. Results After treatment,the plasma viscosity,whole blood high shear viscosity and fibrinogen level of the observation group were lower than those of the control group,and the differences between the groups were statistically significant (P<0.05);the levels of superoxide dismutase and total antioxidant capacity in the observation group were higher than those in the control group,and the level of malondialdehyde was lower than that in the control group,and the differences between the groups were statistically significant (P<0.05);the National Institute of Health Stroke Scale score of the observation group was (4.53±0.96) points,which was lower than (5.97±1.39) points of the control group,and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Ginkgo leaf extract and dipyridamole combined with edaravone injection can improve hemorheological indicators,oxidative stress response,promote neurological function recovery in patients with ACI,and has a low adverse reaction rate and good safety.
Acute cerebral infarctionGinkgo leaf extract and dipyridamoleEdaravoneHemorheologyOxidative stress responseNeurological function
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