Clinical Effect of Local Mild Hypothermia Combined with Nimodipine and Alprostadil in the Treatment of Cerebral Vasospasm after Subarachnoid Hemorrhage
Objective To investigate the effect of local mild hypothermia combined with nimodipine and alprostadil in the treatment of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SHA). Methods Sixty patients with CVS after SHA admitted to Changqing District People's Hospital of Jinan City from April 2021 to May 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group. The control group was treated with local mild hypothermia combined with alprostadil,and the observation group was treated with nimodipine based on the control group. The incidence of CVS,cerebral artery blood flow velocity and clinical efficacy of the two groups were compared. Results The incidence of CVS in the observation group was 13.33％,which was lower than 50.00％ in the control group,and the difference was statistically significant (P<0.05). After treatment,the blood flow velocity of anterior cerebral artery,middle cerebral artery and posterior cerebral artery in the observation group were slower than those in the control group,and the differences between the groups were statistically significant (P<0.05). The total effective rate of the observation group was 93.33％,which was higher than 73.33％ of the control group,and the difference was statistically significant (P<0.05). Conclusion Local mild hypothermia combined with nimodipine and alprostadil in the treatment of CVS after SHA has a significant effect,which is conducive to reducing the occurrence of CVS and improving cerebral arterial blood flow velocity.
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