Effect of Vancomycin Combined with Meropenem in Patients with Postoperative Intracranial Infection after Severe Traumatic Brain Injury
Objective To analyze the effects of vancomycin combined with meropenem in patients with intracranial infection after severe traumatic brain injury surgery. Methods Eighty patients with intracranial infection after severe craniocerebral injury surgery at the Neurosurgery Department of Lanling County People's Hospital from May 2018 to May 2022 were selected as the research subjects. According to the random number table method,they were divided into a control group and an observation group,with 40 patients in each group. The control group underwent lumbar spinal drainage to release cerebrospinal fluid and were given intrathecal injection of vancomycin for anti infection treatment. The observation group received combined use of meropenem on this basis of the control group. Compare the clinical efficacy,inflammatory response index levels,cerebrospinal fluid routine index levels,and incidence of adverse reactions between two groups. Results The observation group had a symptom resolution time of (11.50±2.50)days,which was shorter than (13.50±2.50)days in the control group,and the difference was statistically significant (P<0.05). The cure rate of the observation group was higher than that of the control group,and the difference was statistically significant (P<0.05). There was no statistically significant difference in the remission rate between the two groups(P>0.05). After treatment,the levels of C-reactive protein,interleukin-1ß,and tumor necrosis factor-a in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05);the white blood cell count and S-100 protein level in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion The use of vancomycin combined with meropenem in the treatment of postoperative intracranial infection in patients with severe traumatic brain injury is beneficial for promoting symptom disappearance,inhibiting intracranial inflammatory cerebrospinal fluid,and does not increase the incidence of serious adverse reactions.
Severe traumatic brain injuryIntracranial infectionVancomycinMeropenemIntrathecal injectionInflammatory reaction
NETL
NSTL
万方数据
