Effects of Idarubicin Combined with Cytarabine on Hematological Indicators and Immune Function of Children with Acute Myeloid Leukemia
Objective To investigate the effects of idarubicin combined with cytarabine on hematologic indicators and immune function in children with acute myeloid leukemia(AML).Methods Forty-eight children with AML admitted to Linyi Central Hospital from January 2020 to December 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 24 cases in each group.The control group was treated with daunorubicin combined with cytarabine,and the observation group was treated with idarubicin combined with cytarabine.The clinical efficacy,hematological indicators,immune function and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 66.67%,which was higher than 37.50%of the control group,the difference was statistically significant(P﹤0.05).After treatment,the levels of soluble intercellular adhesion molecule-1,soluble vascular cell adhesion molecule-1 and hemoglobin in both groups were lower than those before treatment,and the observation group was lower than those in the control group,and the white blood cell count level in both groups were higher than those before treatment,and the observation group was higher than that in the control group,the differences were statistically significant(P﹤0.05);the levels of CD4+and CD4+/CD8+in both groups were higher than those before treatment,and the observation group were higher than those in the control group,and the level of CD8+in both groups were lower than those before treatment,and the observation group was lower than that in the control group,the differences were statistical significance(P﹤0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P﹤0.05).Conclusion Treatment with daunorubicin combined with cytarabine in children with AML is beneficial to improve clinical efficacy,hematological indicators and immune function,and is safe and reliable.
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