Analysis of Clinical Effect of Combined Treatment of Human Menopausal Gonadotropins and Letrozole in Clomiphene Resistance to PCOS Infertility Patients
Objective To investigate the clinical effect of human menopausal gonadotropins(HMG)and letrozole in the treatment of clomiphene resistance in polycystic ovary syndrome(PCOS)infertility patients.Methods Eighty clomiphene resistance PCOS infertility patients admitted to Rencheng District Maternal and Child Health Hospital in Jining City from June 2021 to June 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 40 cases in each group.The control group was treated with letrozole and the observation group was treated with HMG on the basis of the control group.The assisted reproductive indicators,estrogen,pregnancy,ovulation and abortion,and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the number of follicles≥18 mm on human chorionic gonadotropin injection day in the observation group was higher than that in the control group,the endometrial thickness was thicker than that in control group,the maturation time of follicles was shorter than that in the control group,and the uterine volume was larger than that in the control group,and the differences between the groups were statistical significance(P﹤0.05);the follicle-stimulating hormone in observation group was higher than that in the control group,estradiol and luteinizing hormone were lower than those in the control group,and the differences between the groups were statistically significant(P﹤0.05);the pregnancy rate and ovulation rate in the observation group were 52.50%and 67.50%,respectively,which were higher than 30.00%and 45.00%in the control group,and the differences between the groups were statistical significance(P﹤0.05);there was no significant difference in the rate of abortion and incidence of adverse reactions between the two groups(P﹥0.05).Conclusion In clomiphene resistance to PCOS infertility patients,the treatment of human menopausal gonadotropins combined with letrozole can effectively improve the assisted reproductive indicators,estrogen levels,ovulation rate and pregnancy rate,and the drug is safe.
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