ACI患者血清Hcy、hs-CRP和TGF-β1检测的临床意义
Clinical Significance of Measurement on the Changes of Serum Hcy,hs-CRP and TGF-β1 Levels in Patients with Acute Cerebral Infarction(ACI)
杜莉 1王延稳 1段大磊1
作者信息
摘要
目的:探讨了急性脑梗死(ACI)患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化及临床意义.方法:应用免疫化学法、免疫比浊法和放射免疫分析对32例ACI患者进行了治疗前后血清Hcy、hs-CRP和TGF-β1检测,并与35名正常健康人作比较.结果:ACI患者在治疗前血清Hcy、hs-CRP和TGF-β1水平均非常显著地高于正常人组(P<0.01),经治疗1个月后则与正常人组比较无显著性差异(P>0.05).血清Hcy水平与hs-CRP、TGF-β1水平呈正相关(r=0.6146、0.5784,P<0.01).结论:检测ACI患者治疗前后血清Hcy、hs-CRP和TGF-β1水平的变化对了解病情、观察预后均具有重要的临床价值.
Abstract
Objective To explore the clinical significance of measurement on the changes of serum Hey,hs-CRP and TGF-pilevels after treatment in patients with ACE. Methods Serum Hcy(with immunochemistry) , serum hs-CRP (with immunoturbidime-try) , serum TGF-β1 (with RIA) levels were determined in 32 patients with ACI and 35 normal healthy controls. Results Before treatment,serum Hcy,hs-CRPand TGF-pl levels in the patients were significantly higher than those in controls (P ＜0.01). After treatment for 1 month,serum Hey, hs-CRF and TGF-pl levels were no significant difference (P ＞0.05). Serum Hey level showed positively correlated with hs-CRP,TGF-pl levels (r=0.6146,0.5784,P＜0.01). Conclusion Detection the changes of serum Hey, hs-CHP and TGF-pl levels after treatment in patient with ACI might be helpful to monitor efficacy of therapy and prognosis. Therefore, possess important clinical value.TGF
关键词
急性脑梗死/同型半胱氨酸/超敏C-反应蛋白/转化生长因子-β1Key words
acute cerebral infarction(ACl)/homocysteine(Hey)/hyper sencititive C-reactive protein (hs-CRF)/transforming growth factor-β1 ( TGF-β1)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据