血浆ANF与99mTc-DTPA肾动态显像的联合监测在糖尿病肾病中的意义
Plasma ANF and 99mTc-DTPA Renal Dynamic Imaging Combined Monitoring in the Significance of Diabetic Nephropathy
余飞 1吕明丽 1蔡海东 1李丹 1袁雪宇 1吕中伟1
作者信息
- 1. 同济大学附属第十人民医院核医学科,200072
- 折叠
摘要
目的:通过血浆ANF与99mTc-DTPA肾动态显像的联合测定,对糖尿病肾病(DN)进行准确的诊断和临床分期.方法:选取我院70例2型糖尿病(DM2)患者(排除心、脑、血管疾病、泌尿系感染)及正常健康者40名作为正常对照组.70例DM2患者分为2组,A组35例为早期DN组,糖尿病病程为(5~10)年,血BUN、Cr没有明显变化,B组35例为中晚期DN组,糖尿病病程>10年,血BUN、Cr有不同程度升高.分别测定血浆ANF和GFR.结果:A组及B组ANF含量均高于正常对照组(P<0.01),且B组明显高于A组(P<0.01);A组GFR测定高于正常对照组(P<0.05),B组GFR低于正常对照组(P<0.01).结论:实验表明,DN早期GFR值升高,ANF值升高,中晚期DN患者GFR值降低,但ANF值升高更为明显.
Abstract
Objective The study examined GFR by the 99mTc-DTPA renal dynamic imaging and plasma ANF to get the diabetic nephropathy's definite diagnosis and the clinical stages. Methods selected 70 patients with type 2 diabetes in our hospital ( barring the heart, brain, vascular diseases and urinary tract infection) and 40 normal healthy persons served as control group. 70 cases of type 2 diabetes patients were divided into two groups, Group A with 35 cases of early diabetic nephropathy, duration of diabetes for 5-10 years, blood BUN, Cr changed unsignificantly, Group B with 35 cases of middle-late diabetic nephropathy, duration of diabetes ＞10 years, blood BUN, Cr showed different levels rising. Results ANF examination, both of A group and B were higher than those in control group, the difference is highly significant (P ＜0.05) and B group obviously higher than the group A, the difference is highly significant (P＜0.05) ; GFR examination, the group A higher than that of control group, the difference is significant (P ＜0.05), group B manifested below the control group, the difference showed markedly significant (P＜0.05) Conclusion The experiment indicated, in early stage of diabetic nephropathy GFR is increasing and ANF also increasing, diabetic nephropathy in middle-late stage GFR is reducing but ANF is increasing more obviously.
关键词
糖尿病肾病/血浆心钠素/放射免疫分析/肾小球滤过率Key words
diabetic nephropathy/plasma ANF/radioimmunoassay(RIA)/GFR引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据