卵巢癌患者手术前后血清HE4、CA125和SIL-2R检测的临床意义
Clinical Significance of Measurement the Changes of Serum HE4, CA125 and SIL-2R Levels Both Before and After Operation in Patients with Ovarian Cancer
时步卿1
作者信息
摘要
目的:探讨卵巢癌患者手术治疗前后血清HE4、CA125和SIL-2R水平的变化及临床意义.方法:应用放射免疫分析、酶联法对33例卵巢癌患者进行治疗前后血清HE4、CA125和SIL-2R检测,并与35名正常健康人作比较.结果:卵巢癌患者手术前血清HE4、CA125和SIL-2R水平非常显著地高于正常人组(P＜0.01).手术治疗3个月后则与正常人组比较无显著性差异(P＞0.05).血清HE4水平与CA125、SIL-2R水平呈显著正相关(r=0.5784、0.6122,P＜0.01).结论:检测卵巢癌患者手术治疗前后血清HE4、CA125和SIL-2R水平的变化与该病的发生和发展密切相关.
Abstract
Objective To explore the clinical significance of measurement the changes of serum HE4, GA125 and SIL - 2R levels both before and after operation in patients with ovarian cancer. Methods Serum GA12S (with RIA) , serum HE4, SIL-2R(with FLISA) levels were measured in 33 patients with ovarian cancer both before and after operation as well as in 35 normal healthy controls. Results Before operation serum HE4, CA125 and SIL -2R in patients with ovarian cancer were significantly higher than those in controls (P ＜ 0.01). 3 months after operation the levels dropped markedly to normal in comparison with controls( P＞0.05 ). Serum HE4 Level was positively correlated with serum CA125, SIL-2R levels (r =0.5784, 0.6122, P＜0.01). Conclusion The serum HE4, CA125 and SIL-2R levels both before and after operation in patients with ovarian cancer closely related to the progress of the diseases.
关键词
卵巢癌/人附睾蛋白4/糖类抗原-125/白细胞介素-2受体Key words
ovarian cancer/haman epididymis protein-4(HE-4)/carbohydrate antigen -125(CA-125) ,interleukin-2 receptors (SIL-2R)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据