原发性高血压患者血浆ET-1水平与脂质过氧化关系的探讨
A Study on the Relationship Between the Plasma ET-1 Level and Lipid Peroxidation in Patients with Primary Hypetension
左新春1
作者信息
- 1. 江苏省沭阳县仁慈医院心内科,223600
- 折叠
摘要
目的:探讨原发性高血压患者血浆ET-1水平与脂质过氧化的关系.方法:分别应用放免法和生化法对33例高血压患者进行血浆ET-1、丙二醛(MDA)、超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量测定,并与35名正常健康人作比较.结果:原发性高血压患者血浆ET-1、MDA水平非常显著地高于正常人组(P<0.01),而血清SOD、GSH-PX水平非常显著地低于正常人组(P<0.01).相关分析显示,血清SOD、GSH-PX水平与MDA水平呈显著负相关(r=-0.4218、-0.4011,P<0.01).结论:原发性高血压患者血清SOD、GSH-PX水平的降低与活性代谢紊乱密切相关.
Abstract
Objective To assess the relationship between the plasma ET-1 level and lipid penoxdation in patients with primary hypertension. Methods Plasma ET-1 (with ELBA) , serum MDA, SOD and GSH-FX (with biochemistry) levels were measured in 33 patients with primary hypertension and 35 normal controls. Results Plasma ET-1, MDA levels were significantly higher in patients with primary hypertension than those in oon!rols＜P＜0.01),but serum SOD, GSH-PX levels were obviously lower(P＜0.01). Serum SOD, GSH-PX levels were negatively correlated with MDA level (r = -0.4218,-0.4011,P＜0.01). Conclusion Decreases of serum SOD, GSH-FX levels were closely related with the disorder of active metabolism in patients with primary hypertension.
关键词
原发性高血压/内皮素/丙二醛/超氧化物岐化酶/谷胱甘肽过氧化物酶Key words
primary hypertension/endothelin-1 ( ET-1)/malondialdohyde( MDA)/superozide dismutase(SOD)/glutathione penmdase( GSH-FX)引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据