Objective To investigate serum biomarker changes both before and after treatment of acute coronary syndrome (ACS)patients and its clinical significance. Methods Serum concentrations of two biomarkers (NT-proBNP, hs-cTnT) were detected in 135 patients with ACS, in which the ST segment elevation acute myocardial infarction ( STEAM) were 71 cases and non ST segment elevation acute myocardial infarction (NSTEAMI) were 34 cases; unstable angina pectoris (UAP) were 30 cases, 30 patients with negative coronary artery angiography ( CAG) were established as the control group. All subjects were tested NT-proBNP, hs-cTnT concentrations before and after the treatment of ACS. Results ACS group serum NT-proBNP, hs-cTnT levels were higher than the control group, the difference was statistically significant (P＜0.05). NSTEAMI Group NT-proBNP levels superior than those in STEA-M group and UAP group (P＜0.05) , hs-cTnT levels in ACS group had a significant difference (P＜0.05) , the two biomarkers increased markedly within 24 h in patients with STEAMI, whereas no changes in the two biomarkers were noted in patients with NSTEAMI and UAP, in all group, the two biomarkers decreased obviously 96 h after successful reperfuaion. NT-proBNP displayed a strong correlation with hs-cTnT (r = 0.625, P ＜ 0. 05 ). Conclusion Dynamic monitoring serum biomarkers changes after treatment of ACS, has a positive clinical significance for clinical observation and prognosis.
NETL
NSTL
维普
万方数据
