血浆IL-18浓度与脑出血预后的相关性探讨
Study on the Relationship Between Plasma Interleukin-18 Concentration and the Outcomes of Intracerebral Hemorrhage
杨志辉 1陈宜德 1吴晓玉1
作者信息
- 1. 浙江省台州市第一人民医院EICU,318020
- 折叠
摘要
目的:探讨脑出血患者血浆白介素-18(IL-18)浓度与预后的相关性.方法:选取脑出血患者80例,ELISA检测血浆IL-18浓度,统计分析其与患者预后的相关性.结果:血浆IL-18浓度与脑出血患者入院时GCS评分、血肿量和脑室积血有显著相关性(均P<0.01),是脑出血后1年内死亡的独立危险因素(OR=1.328,95%CI=1.017~2.682,P<0.01),对脑出血后1年内死亡有显著预测价值(P<0.01),且有较高的特异度和灵敏度.结论:IL-18与脑出血预后显著相关,临床检测这个指标有助于早期评估脑出血患者死亡.
Abstract
Objective This study aimed to explore the correlativity between the level of interleukin-18(IL-18) in plasma and the outcomes of the patients with intracerebral hemorrhage. The change of plasma IL-18 and prognosis on patients were analysed statistically. Methods Eighty patients with intracerebral hemorrhage were included in our group. Concentration of IL-18 in plasma was measured with EUSA. Results Plasma IL-18 was highly associated with CCS score, hematoma volume and presence of intraventricular hemorrhage of patients (all P＜0.01), identified as a independent risk factor of 1 -year mortality(OR = 1.328, 95% CI = 1.017～ 2.682, P ＜ 0.01) , and predicted 1 -year mortality with the high sensitivity and specificity( P ＜ 0.01). Conclusion Interleukin-18 is obviously correlated with prognosis of intracerebral hemorrhage, and its clinical determination will be helpful for the early to evaluate the mortality of intracerebral hemorrhage.
关键词
白介素-18/脑出血/预后Key words
interleukin-18 (IL-18)/intracerebral hemorrhage/prognosis引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据