糖尿病并发大血管病变患者sCD163与oxLDL-Ab检测的临床价值
Clinical Value of sCD163,oxLDL-Ab Detecting in Diabetic Macroangiopathy
赵荣泽 1赵中强1
作者信息
摘要
目的:探讨老年2型糖尿病(DM2)患者血清可溶性单核-巨噬细胞血红蛋白清道夫受体(sCD163)和抗氧化型低密度脂蛋白抗体(oxLDL-Ab)与大血管病变的关系.方法:测定 189例DM2患者及50例正常对照者sCD163和oxLDL-Ab水平,189例DM2患者分为大血管病变组(120例)与无大血管病变组(69例),比较三组间sCD163和oxLDL-Ab水平,并进行相关性分析.结果:与正常对照组比较DM2组sCD163与oxLDL-Ab水平较高、DM合并大血管病变组sCD163与oxLDL-Ab水平高于DM无血管病变组,各组间有显著性差异(P<0.05,P<0.05),且sCD163与oxLDL-Ab水平呈正相关(r=0.45,P<0.05).结论:sCD163与oxLDL-Ab与DM2大血管病变的发生发展密切相关,且联检可对早期动脉硬化的诊断具有重要的指导意义.
Abstract
Objective To explore the elderly type 2 diabetes mellitus (DM2) patients on serum soluble macrophage hemoglobin scavenger receptor (sCD163) and oxidized low density lipoprotein antibody (oxLDL-Ab) and its relationship with macrovascular diseases. Methods sCD163 and oxLDL-Ab were measured in 189 diabetics and SO healthy controls 189 patients with diabetes mellitus, divided into large vascular lesion group (120 cases) and no major vascular lesion group (69 cases) , a comparison of three groups with sCD163 and oxLDL-Ab level, and the analysis of were made correlation. Results Compared to normal group, the diabetes group sCD163and oxLDL-Ab levels were higher, DM with large blood vessel lesion group sCD163and axLDL-Ab levels higher than those in DM without vascular lesion group, each group manifested statistical significance (P＜0.05,P＜0.05), and sCD163and axLDL-Ab levels are positively correlated (r=0.45, P＜0.05). Conclusion sCD163and axLDL-Ab and diabetic macrovasciuar disease occurrence is closely related to the development and combined detection of early arteriosclerosis diagnosis provides important guiding significance.
关键词
糖尿病/大血管病变/可溶性单核巨噬细胞血红蛋白清道夫受体/氧化型低密度脂蛋白抗体Key words
diabetes mellitus/vascular lesions/soluble macrophage hemoglobin scavenger receptor/oxidized low density lipoprotein antibody引用本文复制引用
出版年
2013
NETL
NSTL
维普
万方数据