Objective To measure the levels of soluble P-selectin, platelet count and hs-CRP in colorectal cancer patients,and the relationship between platelet activation and inflammation. Methods 45 colorectal cancer patients and 32 healthy subjects were recruited to our reseach,and colorectal cancer patients were divided into two groups; group A and group B. To measure the levels of soluble P-selectin, platelet count and hs-CRP respectively, and analyzed statistically. Results Soluble P-selectin and CBP levels were significantly increased as compared to the control group (P＜0.001). Serum levels of sP-selectin and hs-CRP were markedlyhigher in group B (with metastases) than in group A (P＜0.001). Conclusion The experiment indicated hyperactivation of blood platelets and inflammatory response in patients with colorectal cancer, also the inflammatory process and platelet activation progress along with colorectal cancer advancement, and the correlation of platelet activation with inflammatory response in colorectal cancer patients.
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维普
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