慢性丙型肝炎患者红细胞CR1黏附活性与血清TGF-β1水平的关系
The Relationship Between the Adherence Activity of Erythrocyte Complement Receptor 1(CR 1) and Serum TGF-β1 Levels in Patients with Chronic Hepatitis C
陈岩 1张玉红2
作者信息
- 1. 江苏省连云港市东海县石榴乡中心卫生院,222300
- 2. 江苏省连云港市东海县人民医院,222300
- 折叠
摘要
目的:探讨慢性丙型肝炎患者红细胞CR1黏附活性与血清TGF-β1水平的相关性.方法:采用红细胞天然免疫功能试验和酶联法对32例慢性丙型肝炎患者进行了红细胞CR1黏附活性测定和血清TGF-β1测定,并与35名正常健康人作比较.结果:慢性丙型肝炎患者红细胞CR1黏附活性显著地低于正常人组(P<0.01),血清TGF-β1水平非常显著地高于正常人组(P<0.01),红细胞CR1黏附活性的变化与TGF-β1水平相关.结论:慢性丙型肝炎患者红细胞CR1黏附活性与TGF-β1水平相关,对判断病情的轻重、发生和发展具有一定的临床价值.
Abstract
Objective To explore the correlativity between changes of adheremce activity of erythrocyte CR1 and serum TGF-β1 levels in patients with chronic hepatic C. Methods Erythiocyte CR1 adherence activity was detected with erythrocyte immune function test and serum TGF-p, level with ELLSA in 32 patients with chronic hepatic C and compared to 35 normal healthy controls. Results The erythrocyte GR1 adherence activity in patients with chronic hepatic C showed significantly lower than that controls(P ＜0. 01) , While the serum TGF-β1 level was markedly higher than that in controls(P＜0.01). The change of CR1 adherence activity was closely correlated with the change of serum TGF-β1 level. Conclusion Change of erythrocyte CRl adherence activity was closely correlated with the serum TGF-β1. Also, provides certain clinical value to predict the severity of pathosis, pathogeny and development
关键词
慢性丙型肝炎/红细胞/受体/补体/转化生长因子-β1Key words
chronic hepatic C/erythrocyte,receptor/complement,transforming growth factor-β1(TGF-β1)引用本文复制引用
出版年
2013
NETL
NSTL
万方数据